Bcl6btm1Dtf
Targeted Allele Detail
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| Symbol: |
Bcl6btm1Dtf |
| Name: |
B cell CLL/lymphoma 6, member B; targeted mutation 1, Douglas T Fearson |
| MGI ID: |
MGI:3584139 |
| Synonyms: |
Bcl5b- |
| Gene: |
Bcl6b Location: Chr11:70114954-70120624 bp, - strand Genetic Position: Chr11, 42.99 cM, cytoband B4
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| Alliance: |
Bcl6btm1Dtf page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:99818
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting construct was designed such that nucleotides 14-114 of exon 2, encoding codons 1-33, were replaced with a human CD2 reporter cDNA and a loxP-flanked neomycin resistance gene in reverse orientation. Three copies of the SV40 poly A signal were inserted into exon 3. The first downstream in-frame methionine was at codon 119, distal to the poxvirus and zinc finger domain. Northern blot of mutant lung samples revealed a truncated transcript of 0.53 kb, and that the inserted sequence altered the normal splicing of the transcript.
(J:99818)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Bcl6b Mutation: |
14 strains or lines available
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| Original: |
J:99818 Manders PM, et al., BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7418-25 |
| All: |
1 reference(s) |
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Analysis Tools
