Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akt3tm1Hem
Name:	thymoma viral proto-oncogene 3; targeted mutation 1, Brian A Hemmings
MGI ID:	MGI:3580101
Synonyms:	Akt3-, Pkbgamma-
Gene:	Akt3  Location: Chr1:176847639-177085769 bp, - strand  Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
Alliance:	Akt3tm1Hem page

Germline Transmission:	Earliest citation of germline transmission: J:98804
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An IRES-lacZ-neo cassette was inserted into exon 4. Quantitative RT-PCR and Western blot confirmed absence of transcript and protein in mutant brain samples. (J:98804)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt3 Mutation:	42 strains or lines available

Original:	J:98804 Tschopp O, et al., Essential role of protein kinase B{gamma} (PKB{gamma}/Akt3) in postnatal brain development but not in glucose homeostasis. Development. 2005 Jul;132(13):2943-54
All:	13 reference(s)