Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irf7tm1Ttg
Name:	interferon regulatory factor 7; targeted mutation 1, Tadatsugu Taniguchi
MGI ID:	MGI:3577089
Synonyms:	Irf7-
Gene:	Irf7  Location: Chr7:140843096-140846412 bp, - strand  Genetic Position: Chr7, 86.57 cM, cytoband F5
Alliance:	Irf7tm1Ttg page

Germline Transmission:	Earliest citation of germline transmission: J:97662
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-betageo was inserted to replace exons 2 and 3. Northern and Western blot confirmed ablation of transcript and protein. (J:97662)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Irf7 Mutation:	23 strains or lines available

Original:	J:97662 Honda K, et al., IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005 Apr 7;434(7034):772-7
All:	155 reference(s)