Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rhpn2tm1Ssch
Name:	rhophilin, Rho GTPase binding protein 2; targeted mutation 1, Stephanie Schurmans
MGI ID:	MGI:3577068
Synonyms:	Rhpn2-
Gene:	Rhpn2  Location: Chr7:35033605-35091712 bp, + strand  Genetic Position: Chr7, 21.36 cM
Alliance:	Rhpn2tm1Ssch page

Germline Transmission:	Earliest citation of germline transmission: J:97638
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The last 28 nucleotides of exon 7 and about 1 kb of intron 7 were replaced by a neomycin resistance gene. Northern and Western blot of mutants confirmed absence of transcript and protein in brain and kidney samples. (J:97638)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhpn2 Mutation:	40 strains or lines available

Original:	J:97638 Behrends J, et al., Normal thyroid structure and function in rhophilin 2-deficient mice. Mol Cell Biol. 2005 Apr;25(7):2846-52
All:	2 reference(s)