Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Adamts1tm1Mapr
Name:	ADAM metallopeptidase with thrombospondin type 1 motif 1; targeted mutation 1, Melanie A Pritchard
MGI ID:	MGI:3574351
Gene:	Adamts1  Location: Chr16:85590715-85600001 bp, - strand  Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
Alliance:	Adamts1tm1Mapr page

Germline Transmission:	Earliest citation of germline transmission: J:96781
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 2 was deleted via cre-mediated recombination, removing the metalloproteinase domain and, if normal splicing occurred, would result in a frame shift leading to a truncated protein containing only a pre-/pro-domain only. Northern blot using a probe containing exons 4-8 indicated the absence of transcript. Immunohistochemistry further demonstrated the absence of expression in null ovaries. (J:96781)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Adamts1tm1Mapr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adamts1 Mutation:	64 strains or lines available

Original:	J:96781 Mittaz L, et al., Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod. 2004 Apr;70(4):1096-105
All:	7 reference(s)