Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Edn1tm1.1Ywa
Name:	endothelin 1; targeted mutation 1.1, Masashi Yanagisawa
MGI ID:	MGI:3573945
Synonyms:	dlox, Edn1tm1Hhua, ET-1dlox
Gene:	Edn1  Location: Chr13:42454952-42461466 bp, + strand  Genetic Position: Chr13, 20.82 cM
Alliance:	Edn1tm1.1Ywa page

Germline Transmission:	Earliest citation of germline transmission: J:96386
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2, and a neo-thymidine kinase selection cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. (J:96386, J:196635)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Edn1 Mutation:	25 strains or lines available

Original:	J:96386 Huang H, et al., Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. Clin Sci (Lond). 2002 Aug;103 Suppl 48:263S-266S
All:	2 reference(s)