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Phox2a/Inppl1tm1Ssch
Targeted Allele Detail
Summary
Symbol: Phox2a/Inppl1tm1Ssch
Name: paired-like homeobox 2a; targeted mutation 1, Stephane Schurmans
MGI ID: MGI:3531321
Synonyms: SHIP2-
Gene: Phox2a  Location: Chr7:101467520-101471933 bp, + strand  Genetic Position: Chr7, 54.66 cM
Alliance: Phox2a/Inppl1tm1Ssch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96443
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation details7.3 kb genomic sequence containing C-terminal of two genes, Inppl1 and Phox2a were disrupted by the integration of a single targeting construct. A neomycin selection cassette replaced sequence extending from Inppl1 (exons 19-29) and Phox2a (exon 3). (J:96443)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phox2a Mutation:  10 strains or lines available
References
Original:  J:96443 Clement S, et al., The lipid phosphatase SHIP2 controls insulin sensitivity. (Erratum: Nature 2004 Oct 14;4131(7010):878). Nature. 2001 Jan 4;409(6816):92-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory