Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cckartm1Kym
Name:	cholecystokinin A receptor; targeted mutation 1, Kyoko Miyasaka
MGI ID:	MGI:3529601
Synonyms:	CCK-1R-, CCK-AR-
Gene:	Cckar  Location: Chr5:53855827-53865046 bp, - strand  Genetic Position: Chr5, 29.52 cM
Alliance:	Cckartm1Kym page

Germline Transmission:	Earliest citation of germline transmission: J:96137
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1 and all of exon 2, encoding the first 122 amino acids and the first transmembrane-spanning region, was replaced with an NLS-lacZ neo. Northern blot analysis of mutant kidneys demonstrated a complete lack of transcript.. (J:96137)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cckar Mutation:	41 strains or lines available

Original:	J:96137 Takiguchi S, et al., Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice. Pancreas. 2002 Apr;24(3):276-83
All:	10 reference(s)