Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Umodtm1Xrw
Name:	uromodulin; targeted mutation 1, Xue-Ru Wu
MGI ID:	MGI:3526897
Synonyms:	THP-
Gene:	Umod  Location: Chr7:119061931-119078485 bp, - strand  Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
Alliance:	Umodtm1Xrw page

Germline Transmission:	Earliest citation of germline transmission: J:95431
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-4 and a 650 bp proximal promoter region were replaced with a neomycin cassette. RT-PCR and Northern blot analysis demonstrated the lack of transcript in mutant kidneys. Immunohistochemistry and Western blot showed that no protein was present in mutant mice. (J:95431)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Umod Mutation:	4 strains or lines available

Original:	J:95431 Mo L, et al., Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol. 2004 Apr;286(4):F795-802
All:	15 reference(s)