Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ghrtm1Mwat
Name:	growth hormone receptor; targeted mutation 1, Michael J Waters
MGI ID:	MGI:3526104
Synonyms:	m569
Gene:	Ghr  Location: Chr15:3347237-3612834 bp, - strand  Genetic Position: Chr15, 1.84 cM
Alliance:	Ghrtm1Mwat page

Germline Transmission:	Earliest citation of germline transmission: J:95149
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: A targeting vector was designed to truncate the protein at proline 569 and convert Y539/545F. Northern and Western blotting of mutant hepatic tissue confirmed the mutation and protein truncation. (J:95149)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ghr Mutation:	49 strains or lines available

Original:	J:95149 Rowland JE, et al., In vivo analysis of growth hormone receptor signaling domains and their associated transcripts. Mol Cell Biol. 2005 Jan;25(1):66-77
All:	5 reference(s)