Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irag1tm1Jens
Name:	inositol 1,4,5-triphosphate receptor associated 1; targeted mutation 1, Jens Schlossmann
MGI ID:	MGI:3525059
Synonyms:	Iragdelta12
Gene:	Irag1  Location: Chr7:110467473-110581668 bp, - strand  Genetic Position: Chr7, 57.9 cM
Alliance:	Irag1tm1Jens page

Germline Transmission:	Earliest citation of germline transmission: J:94387
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 12 encodes the amino-terminal part of the coiled-coil domain, and was deleted upon Cre expression from a Cre-deleter mouse. Western blot showed the presence of a smaller protein than wild-type in mutant stomach samples, corresponding to the loss of exon 12 coding sequence. (J:94387)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irag1 Mutation:	50 strains or lines available

Original:	J:94387 Geiselhoringer A, et al., IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. EMBO J. 2004 Oct 27;23(21):4222-31
All:	1 reference(s)