Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfrsf10btm1Wnt
Name:	tumor necrosis factor receptor superfamily, member 10b; targeted mutation 1, Astar Winoto
MGI ID:	MGI:3522001
Synonyms:	TRAIL-R-
Gene:	Tnfrsf10b  Location: Chr14:70004921-70021860 bp, + strand  Genetic Position: Chr14, 36.1 cM
Alliance:	Tnfrsf10btm1Wnt page

Germline Transmission:	Earliest citation of germline transmission: J:94681
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed to replace a portion of exon 5, containing the transmembrane domain, and exon 6 with a neomycin resistance gene. RT-PCR of multiple tissues demonstrated a lack of transcript in mutant mice. (J:94681)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf10b Mutation:	28 strains or lines available

Original:	J:94681 Diehl GE, et al., TRAIL-R as a negative regulator of innate immune cell responses. Immunity. 2004 Dec;21(6):877-89
All:	5 reference(s)