Cntn2tm2Furl
Targeted Allele Detail
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| Symbol: |
Cntn2tm2Furl |
| Name: |
contactin 2; targeted mutation 2, Andrew Furley |
| MGI ID: |
MGI:3521785 |
| Synonyms: |
TAG-1a |
| Gene: |
Cntn2 Location: Chr1:132437163-132470989 bp, - strand Genetic Position: Chr1, 57.42 cM
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| Alliance: |
Cntn2tm2Furl page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:137627
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| Parent Cell Line: |
Bruce 4 (ES Cell)
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| Strain of Origin: |
B6.Cg-Thy1a
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| Allele Type: |
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Targeted (Hypomorph, Modified isoform(s)) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 3 through 6 that encode the first three Ig domains of the protein were replaced with a neomycin resistance cassette. Aberrant splicing of exon 2, which encodes the ATG start site and the leader sequence, to exon 7 or 9 produces a minor protein product lacking the first two Ig domains and a major protein product lacking the first three Ig domains. The level of protein expression for the mutant allele was about half that of the wild-type allele. Despite the truncation, mutant protein was expressed on the cell surface of sensory neurons. It was predicted the truncation would interfere with cis binding to the L1 cell surface protein. This is a hypomorph allele.
(J:137627)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cntn2 Mutation: |
53 strains or lines available
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| Original: |
J:137627 Law CO, et al., The neural adhesion molecule TAG-1 modulates responses of sensory axons to diffusible guidance signals. Development. 2008 Jul;135(14):2361-71 |
| All: |
1 reference(s) |
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