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Apctm1Cip
Targeted Allele Detail
Summary
Symbol: Apctm1Cip
Name: APC, WNT signaling pathway regulator; targeted mutation 1, Christine Perret
MGI ID: MGI:3513416
Synonyms: Apcdelta14
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance: Apctm1Cip page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94108
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 13 and a loxP flanked PGK-Hprt cassette into intron 14. Crossing with transgenic mice expressing Cre in the germline excised exon 14 and the Hprt cassette. RT-PCR indicated the lack of transcript in colon samples from mutants. (J:94108)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Apctm1Cip
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  154 strains or lines available
References
Original:  J:94108 Colnot S, et al., Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest. 2004 Dec;84(12):1619-30
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory