Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sv2btm1Baj
Name:	synaptic vesicle glycoprotein 2b; targeted mutation 1, Sandra M Bajjalieh
MGI ID:	MGI:3511830
Gene:	Sv2b  Location: Chr7:74764642-74959010 bp, - strand  Genetic Position: Chr7, 43.62 cM, cytoband D1
Alliance:	Sv2btm1Baj page

Germline Transmission:	Earliest citation of germline transmission: J:70828
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin gene replaced the first coding exon and flanking sequences. Northern blot of of homozygote brain extracts indicated the presence of a truncated mRNA. Western blot analysis of brain homogenates derived from homozygous mice confirmed that no detectable encoded protein was made though the only available antibodies target the amino terminus. (J:148272)

Generation of the Sv2btm1Baj allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sv2b Mutation:	58 strains or lines available

Original:	J:70828 Xu T, et al., SV2 modulates the size of the readily releasable pool of secretory vesicles. Nat Cell Biol. 2001 Aug;3(8):691-8
All:	8 reference(s)