Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Traf2tm1.1Rbr
Name:	TNF receptor-associated factor 2; targeted mutation 1.1, Robert Brink
MGI ID:	MGI:3511496
Synonyms:	Traf2delta
Gene:	Traf2  Location: Chr2:25407994-25436952 bp, - strand  Genetic Position: Chr2, 17.32 cM
Alliance:	Traf2tm1.1Rbr page

Germline Transmission:	Earliest citation of germline transmission: J:93890
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was generated by removing the floxed exon 3 from Traf2tm1Rbr via transient expression of Cre recombinase in recombinant ES cells. Excision of exon 3 resulted in a reading frame shift and introduced a premature stop codon. (J:93890)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf2 Mutation:	25 strains or lines available

Original:	J:93890 Grech AP, et al., TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity. 2004 Nov;21(5):629-42
All:	2 reference(s)