Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ntrk1tm1Tes
Name:	neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Lino Tessarollo
MGI ID:	MGI:3505767
Synonyms:	TrkA-, TrkAneo
Gene:	Ntrk1  Location: Chr3:87685551-87702469 bp, - strand  Genetic Position: Chr3, 38.62 cM
Alliance:	Ntrk1tm1Tes page

Germline Transmission:	Earliest citation of germline transmission: J:93578
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed PGK-neopA was inserted into intron 11. Northern blot and RT-PCR indicated a lack of transcript in dorsal root ganglia of mutants. Upon cre-mediated recombination, expression of the gene is restored. (J:93578)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:	60 strains or lines available

Original:	J:93578 Coppola V, et al., Ablation of TrkA function in the immune system causes B cell abnormalities. Development. 2004 Oct;131(20):5185-95
All:	4 reference(s)