Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ap3m2tm1Ohno
Name:	adaptor-related protein complex 3, mu 2 subunit; targeted mutation 1, Hiroshi Ohno
MGI ID:	MGI:3497921
Synonyms:	mu3Bdeltaneo, mu3B-KO
Gene:	Ap3m2  Location: Chr8:23277370-23295638 bp, - strand  Genetic Position: Chr8, 11.42 cM
Alliance:	Ap3m2tm1Ohno page

Germline Transmission:	Earliest citation of germline transmission: J:93312
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace downstream of the ATG for mu3B in exon 2 with an EGFP and a floxed neo. Cre expression excised the neo. RT-PCR indicated the absence of transcript in mutant brain and spinal cord. EGFP was detected in neurons throughout the brain. (J:93312)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ap3m2 Mutation:	23 strains or lines available

Original:	J:93312 Nakatsu F, et al., Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J Cell Biol. 2004 Oct 25;167(2):293-302
All:	4 reference(s)