Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sh2b1tm1Lr
Name:	SH2B adaptor protein 1; targeted mutation 1, Liangyou Rui
MGI ID:	MGI:3055487
Synonyms:	SH2-B-
Gene:	Sh2b1  Location: Chr7:126066166-126074596 bp, - strand  Genetic Position: Chr7, 69.06 cM
Alliance:	Sh2b1tm1Lr page

Germline Transmission:	Earliest citation of germline transmission: J:92794
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The promoter region through the majority of the coding sequence was replaced with a neomycin resistance gene. All isoforms are predicted to be eliminated and immunoblot confirmed that no wild-type protein was present in mutant livers. (J:92794)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh2b1 Mutation:	48 strains or lines available

Original:	J:92794 Duan C, et al., Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol. 2004 Sep;24(17):7435-43
All:	13 reference(s)