Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Psmb8tm1Hjf
Name:	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); targeted mutation 1, H J Fehling
MGI ID:	MGI:3055222
Synonyms:	beta5i-, LMP-7-, LMP7-
Gene:	Psmb8  Location: Chr17:34417169-34420428 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	Psmb8tm1Hjf page

Germline Transmission:	Earliest citation of germline transmission: J:20012
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-5, encoding the first 247 amino acids of the protein, were replaced with a neomycin resistance gene. (J:20012)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Psmb8 Mutation:	15 strains or lines available

Original:	J:20012 Fehling HJ, et al., MHC class I expression in mice lacking the proteasome subunit LMP-7. Science. 1994 Aug 26;265(5176):1234-7
All:	70 reference(s)