Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Rasgrp2tm1Amg
Name:	RAS, guanyl releasing protein 2; targeted mutation 1, Ann M Graybiel
MGI ID:	MGI:3055135
Synonyms:	CalDAG-GEFI-
Gene:	Rasgrp2  Location: Chr19:6449370-6465246 bp, + strand  Genetic Position: Chr19, 4.58 cM, cytoband A
Alliance:	Rasgrp2tm1Amg page

Germline Transmission:	Earliest citation of germline transmission: J:92864
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A frameshift mutation that results in a premature stop codon at amino acid 37 was introduced via homologous recombination. Immunohistochemistry and western blot analysis confirm the absence of protein in homozygous mutants. (J:92864)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rasgrp2 Mutation:	47 strains or lines available

Original:	J:92864 Crittenden JR, et al., CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med. 2004 Sep;10(9):982-986
All:	20 reference(s)