Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prnptm1Ito
Name:	prion protein; targeted mutation 1, Shigeyoshi Itohara
MGI ID:	MGI:3054245
Synonyms:	Prnp-, Prnp0, Rikn Prnp-
Gene:	Prnp  Location: Chr2:131751848-131780349 bp, + strand  Genetic Position: Chr2, 64.07 cM
Alliance:	Prnptm1Ito page

Germline Transmission:	Earliest citation of germline transmission: J:68801
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced the gene open reading frame and the 3' end of intron 2. Western analysis of lysates from cerebra did not detect protein. (J:68801)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:	150 strains or lines available

Original:	J:68801 Yokoyama T, et al., In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J Biol Chem. 2001 Apr 6;276(14):11265-71
All:	11 reference(s)