Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfrsf1atm1.1Gkl
Name:	tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1.1, George Kollias
MGI ID:	MGI:3053140
Synonyms:	P55deltaNS
Gene:	Tnfrsf1a  Location: Chr6:125326686-125339446 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance:	Tnfrsf1atm1.1Gkl page

Germline Transmission:	Earliest citation of germline transmission: J:92470
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector was designed to delete 15 nucleotides in exon 6 encoding amino acids 202-206. Southern blot and PCR confirmed recombination. Flow cytometry of peritoneal cells indicated that the mutation abolished receptor shedding. Cre-mediated recombination removed the floxed selection cassette. (J:92470)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:	47 strains or lines available

Original:	J:92470 Xanthoulea S, et al., Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med. 2004 Aug 2;200(3):367-76
All:	3 reference(s)