Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pias1tm1Kes
Name:	protein inhibitor of activated STAT 1; targeted mutation 1, Ke Shuai
MGI ID:	MGI:3052227
Synonyms:	Pias1-
Gene:	Pias1  Location: Chr9:62785648-62888161 bp, - strand  Genetic Position: Chr9, 33.91 cM
Alliance:	Pias1tm1Kes page

Germline Transmission:	Earliest citation of germline transmission: J:92167
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-12 were replaced with a PGK-neo cassette. Transcript was absent in Northern blot of mutant testis and Western blot indicated no protein was present in mutant BMM, spleen or thymus. (J:92167)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pias1 Mutation:	43 strains or lines available

Original:	J:92167 Liu B, et al., PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004 Sep;5(9):891-8
All:	5 reference(s)