Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atp2b1tm1Ges
Name:	ATPase, Ca++ transporting, plasma membrane 1; targeted mutation 1, Gary E Shull
MGI ID:	MGI:3051541
Synonyms:	Pmca1-
Gene:	Atp2b1  Location: Chr10:98750268-98862005 bp, + strand  Genetic Position: Chr10, 50.97 cM, cytoband C3
Alliance:	Atp2b1tm1Ges page

Germline Transmission:	Earliest citation of germline transmission: J:91844
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Codons 466-529 in exon 10, including the catalytic phosphorylation site (aspartic acid 475), were replaced with a neomycin resistance gene. Northern blot indicated no difference in levels of mRNA between wild-type and heterozygous mice. RT-PCR confirmed that the exon 9 was spliced to exon 11, producing the transcript of the expected length. (J:91844)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp2b1 Mutation:	65 strains or lines available

Original:	J:91844 Okunade GW, et al., Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. J Biol Chem. 2004 Aug 6;279(32):33742-50
All:	4 reference(s)