Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tacc2tm1Jni
Name:	transforming, acidic coiled-coil containing protein 2; targeted mutation 1, James N Ihle
MGI ID:	MGI:3050542
Synonyms:	Tacc2-
Gene:	Tacc2  Location: Chr7:130179168-130366515 bp, + strand  Genetic Position: Chr7, 73.19 cM, cytoband F4
Alliance:	Tacc2tm1Jni page

Germline Transmission:	Earliest citation of germline transmission: J:91577
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 4 and exons 5-7 were replaced by a neomycin resistance gene. Southern blot confirmed successful recombination and Northern blot showed decreased levels of mRNA in heterozygotes and none in kidneys of homozygous mutants. (J:91577)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tacc2tm1Jni

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacc2 Mutation:	207 strains or lines available

Original:	J:91577 Schuendeln MM, et al., The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol Cell Biol. 2004 Jul;24(14):6403-9
All:	2 reference(s)