Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Btn1a1tm2Ihm
Name:	butyrophilin, subfamily 1, member A1; targeted mutation 2, Ian H Mather
MGI ID:	MGI:3050156
Synonyms:	BtnKO2
Gene:	Btn1a1  Location: Chr13:23641162-23650071 bp, - strand  Genetic Position: Chr13, 9.72 cM
Alliance:	Btn1a1tm2Ihm page

Germline Transmission:	Earliest citation of germline transmission: J:91440
Parent Cell Line:	iTL1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 1.28 kb of 5' flanking sequence, as well as the gene from exon 1A through the 5' region of exon 2 (nucleotides 2912 to 5654) were replaced with an iTLneo selection cassette. Southern blot confirmed recombination and Northern blot demonstrated lack of transcript in mutants. (J:91440)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btn1a1 Mutation:	31 strains or lines available

Original:	J:91440 Ogg SL, et al., Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10084-9
All:	2 reference(s)