Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aplnrtm1Afu
Name:	apelin receptor; targeted mutation 1, Akiyoshi Fukamizu
MGI ID:	MGI:3047284
Synonyms:	APJ-
Gene:	Aplnr  Location: Chr2:84966704-84970267 bp, + strand  Genetic Position: Chr2, 49.45 cM, cytoband E1
Alliance:	Aplnrtm1Afu page

Germline Transmission:	Earliest citation of germline transmission: J:91164
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A promoterless lacZ gene and a neomycin resistance gene replaced a portion of the coding sequence. Southern blot confirmed homologous recombination and Northern blot of mutant heart and lung indicated no transcript was present. (J:91164)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aplnr Mutation:	28 strains or lines available

Original:	J:91164 Ishida J, et al., Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem. 2004 Jun 18;279(25):26274-9
All:	10 reference(s)