Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gnastm2.1Lsw
Name:	GNAS complex locus; targeted mutation 2.1, Lee S Weinstein
MGI ID:	MGI:3043369
Synonyms:	1A-, delta-6267/-1601
Gene:	Gnas  Location: Chr2:174126113-174188537 bp, + strand  Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Alliance:	Gnastm2.1Lsw page

Germline Transmission:	Earliest citation of germline transmission: J:89923
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed fragment from -6267 to -1601 bp upstream of the translation start site was excised via Cre mediated recombination in vivo, resulting in the deletion of Gnas exon 1A regulatory region which regulates tissue-specific imprinting of Gs-alpha. (J:89923)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnas Mutation:	53 strains or lines available

Original:	J:89923 Sakamoto A, et al., Tissue-specific imprinting of the G protein Gsalpha is associated with tissue-specific differences in histone methylation. Hum Mol Genet. 2004 Apr 15;13(8):819-28
All:	3 reference(s)