Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stard3tm1Jfs
Name:	StAR related lipid transfer domain containing 3; targeted mutation 1, Jerome F Strauss III
MGI ID:	MGI:3042568
Synonyms:	MLN64-
Gene:	Stard3  Location: Chr11:98249194-98271938 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance:	Stard3tm1Jfs page

Germline Transmission:	Earliest citation of germline transmission: J:89362
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 10 - 13 were replaced with an IRES-lacZ-Neo fusion gene. This resulted in deletion of most of the StAR-related lipid transfer domain. A truncated 35 kDa protein consisting of exons 1 - 9 fused to exon 14 and containing a frame shift in exon 14 was detected by western blot analysis (J:89362)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stard3 Mutation:	28 strains or lines available

Original:	J:89362 Kishida T, et al., Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J Biol Chem. 2004 Apr 30;279(18):19276-85
All:	1 reference(s)