Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cyp26b1tm1Hmd
Name:	cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1, Hiroshi Hamada
MGI ID:	MGI:3039046
Synonyms:	Cyp26b1-, Cyp26b1tm1Hh
Gene:	Cyp26b1  Location: Chr6:84548396-84570890 bp, - strand  Genetic Position: Chr6, 36.45 cM
Alliance:	Cyp26b1tm1Hmd page

Germline Transmission:	Earliest citation of germline transmission: J:89029
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Homologous recombination was used to replace exons 3-5 and part of 6 with a PGK-puro cassette. These exons encode the heme-binding, steroid-binding and oxygen-binding domains. (J:89029)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	388 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp26b1 Mutation:	35 strains or lines available

Original:	J:89029 Yashiro K, et al., Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell. 2004 Mar;6(3):411-22
All:	19 reference(s)