Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cfbtm1Pkna
Name:	complement factor B; targeted mutation 1, Marcela Pekna
MGI ID:	MGI:3038803
Synonyms:	Cfbtm1Pkny, fB-
Gene:	Cfb  Location: Chr17:35075350-35081492 bp, - strand  Genetic Position: Chr17, 18.41 cM
Alliance:	Cfbtm1Pkna page

Germline Transmission:	Earliest citation of germline transmission: J:47578
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 3 and exons 4-9 were replaced by a neomycin cassette via homologous recombination. These exons contained sequence coding for the entire Ba fragment and a large part of the first serine protease domain. Transcripts from homozygous mutant liver were shorter than that of wild-type mice, putatively the truncated, non-functional transcript from the mutant allele. (J:47578)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfb Mutation:	29 strains or lines available

Original:	J:47578 Pekna M, et al., Mice deficient for the complement factor B develop and reproduce normally. Scand J Immunol. 1998 Apr;47(4):375-80
All:	8 reference(s)