Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Klf5tm1Rng Name: Kruppel-like transcription factor 5; targeted mutation 1, Ryozo Nagai MGI ID: MGI:3038696 Synonyms: Klf5- Gene: Klf5  Location: Chr14:99536127-99550848 bp, + strand  Genetic Position: Chr14, 49.43 cM, cytoband E2.1 Alliance: Klf5tm1Rng page

Pressure overload-induced cardiac hypertophy and fibrosis are reduced in Klf5tm1Rng/Klf5+ mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:78275
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 3' end of exon 2 and all of exon 3 were replaced with a neo cassette by homologous recombination. Western blot analysis showed decreased levels of protein in heterozygotes. (J:78275)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf5 Mutation:	37 strains or lines available

Original:	J:78275 Shindo T, et al., Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002 Aug;8(8):856-63
All:	7 reference(s)