Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Fgf23tm1Tyam Name: fibroblast growth factor 23; targeted mutation 1, Takeyoshi Yamashita MGI ID: MGI:3033408 Synonyms: Fgf23- Gene: Fgf23  Location: Chr6:127049865-127058371 bp, + strand  Genetic Position: Chr6, 61.92 cM Alliance: Fgf23tm1Tyam page

Fgf23tm1Tyam/Fgf23tm1Tyam mice display abnormal bone development Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:88172
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.2 kb genomic fragment encompassing a 5' portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected in the serum of homozygous mutant mice by ELISA. (J:88172)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf23 Mutation:	16 strains or lines available

Original:	J:88172 Shimada T, et al., Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 2004 Feb;113(4):561-8
All:	1 reference(s)