Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gsta4tm1Pzim
Name:	glutathione S-transferase, alpha 4; targeted mutation 1, Piotr Zimniak
MGI ID:	MGI:3032766
Gene:	Gsta4  Location: Chr9:78099248-78116631 bp, + strand  Genetic Position: Chr9, 43.65 cM, cytoband E1
Alliance:	Gsta4tm1Pzim page

Germline Transmission:	Earliest citation of germline transmission: J:87983
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A sequence fragment encompassing the majority of exon 4 and a portion of the following intron was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded amino acids 60 through 91, which have been previously implicated in protein structure and dimerization. Northern and Western blots of a variety of tissues indicated an absence of both transcript and protein in homozygous mutant mice. (J:87983)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gsta4 Mutation:	64 strains or lines available

Original:	J:87983 Engle MR, et al., Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):296-308
All:	12 reference(s)