Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aco1tm1Roua
Name:	aconitase 1; targeted mutation 1, Tracey A Rouault
MGI ID:	MGI:3029223
Synonyms:	IRP1-
Gene:	Aco1  Location: Chr4:40143081-40198338 bp, + strand  Genetic Position: Chr4, 20.24 cM
Alliance:	Aco1tm1Roua page

Germline Transmission:	Earliest citation of germline transmission: J:87889
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-neomycin resistance gene was inserted into exon 13. Protein product was undetectable by Western blot analysis and cytosolic aconitase activity was lost in homozygous mice. (J:87889)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aco1 Mutation:	51 strains or lines available

Original:	J:87889 Meyron-Holtz EG, et al., Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 2004 Jan 28;23(2):386-95
All:	12 reference(s)