Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ripk3tm1Vmd
Name:	receptor-interacting serine-threonine kinase 3; targeted mutation 1, Vishva M Dixit
MGI ID:	MGI:3028853
Synonyms:	rip3-
Gene:	Ripk3  Location: Chr14:56022452-56026314 bp, - strand  Genetic Position: Chr14, 28.19 cM, cytoband C1
Alliance:	Ripk3tm1Vmd page

Germline Transmission:	Earliest citation of germline transmission: J:87683
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A sequence fragment encompassing exons 1 through 3 was replaced with a loxP site flanked neomycin resistance gene cassette. Protein was undetected by Western blot analysis of homozygous mutant MEFs, bone marrow-derived macrophages, B and T lymphocytes, and thymocytes. (J:87683)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

31 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ripk3 Mutation:	31 strains or lines available

Original:	J:87683 Newton K, et al., Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol. 2004 Feb;24(4):1464-9
All:	243 reference(s)