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Nphs2tm1Antc
Targeted Allele Detail
Summary
Symbol: Nphs2tm1Antc
Name: nephrosis 2, podocin; targeted mutation 1, Corinne Antignac
MGI ID: MGI:3028629
Synonyms: Nphs2-
Gene: Nphs2  Location: Chr1:156138297-156155605 bp, + strand  Genetic Position: Chr1, 67.71 cM, cytoband G3
Alliance: Nphs2tm1Antc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87577
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a floxed Pgk-hygromycin cassette inserted in reverse orientation. Absence of transcript and protein product was established by Northern blot analysis and immunofluorescence experiments respectively. (J:87577)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 17 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nphs2 Mutation:  30 strains or lines available
References
Original:  J:87577 Roselli S, et al., Early glomerular filtration defect and severe renal disease in podocin-deficient mice. Mol Cell Biol. 2004 Jan;24(2):550-60
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory