Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdgfrbtm10Sor
Name:	platelet derived growth factor receptor, beta polypeptide; targeted mutation 10, Philippe Soriano
MGI ID:	MGI:2682393
Synonyms:	BetaT
Gene:	Pdgfrb  Location: Chr18:61178222-61218133 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Pdgfrbtm10Sor page

Germline Transmission:	Earliest citation of germline transmission: J:86542
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutation:    Nucleotide substitutions   Mutation details: A frameshift mutation was generated at codon 780, resulting in a nonsense mutation at 801. This stop codon is 11 residues downstream of the RasGAP binding site and precludes the translation of the SHP-2 and PLC-gamma binding sites. (J:86542)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:	84 strains or lines available

Original:	J:86542 Tallquist MD, et al., Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol. 2003 Nov;1(2):288-99
All:	1 reference(s)