Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Eif2ak1tm1Jjch
Name:	eukaryotic translation initiation factor 2 alpha kinase 1; targeted mutation 1, Jane-Jane Chen
MGI ID:	MGI:2679454
Synonyms:	HRI-
Gene:	Eif2ak1  Location: Chr5:143803530-143839535 bp, + strand  Genetic Position: Chr5, 82.67 cM
Alliance:	Eif2ak1tm1Jjch page

Germline Transmission:	Earliest citation of germline transmission: J:85896
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Three exons containing kinase domains VIb - X were replaced with a floxed PGK neomycin gene. The PGK neomicin gene was then removed by cre excision from mice heterozygous for this allele. mRNA transcripts were 404 bp shorter than wild-type. No protein product was detectable by Western blot. (J:85896)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eif2ak1 Mutation:	37 strains or lines available

Original:	J:85896 Han AP, et al., Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J. 2001 Dec 3;20(23):6909-18
All:	14 reference(s)