Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gucy2ctm1Gian
Name:	guanylate cyclase 2c; targeted mutation 1, Ralph A Giannella
MGI ID:	MGI:2678361
Synonyms:	GC-C-, GCC-
Gene:	Gucy2c  Location: Chr6:136674282-136758740 bp, - strand  Genetic Position: Chr6, 66.67 cM
Alliance:	Gucy2ctm1Gian page

Germline Transmission:	Earliest citation of germline transmission: J:43682
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with an hprt cassette inserted by homologous recombination. Transcript was undetected in the jejunum and ileum of homozygous mutant mice by Northern blot analysis. Western blot analysis using an antibody against the extracellular domain indicated the absence of protein in the jejunum. (J:43682)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gucy2c Mutation:	68 strains or lines available

Original:	J:43682 Mann EA, et al., Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion. Biochem Biophys Res Commun. 1997 Oct 20;239(2):463-6
All:	13 reference(s)