Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrig1tm1Ita
Name:	leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1, Sato Itami
MGI ID:	MGI:2675424
Synonyms:	LIG-1-
Gene:	Lrig1  Location: Chr6:94581510-94677139 bp, - strand  Genetic Position: Chr6, 43.15 cM
Alliance:	Lrig1tm1Ita page

Germline Transmission:	Earliest citation of germline transmission: J:77286
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. Neither transcript nor protein was detected in brain tissue of homozygous mutant mice by Northern and Western blot analyses. (J:77286)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrig1 Mutation:	49 strains or lines available

Original:	J:77286 Suzuki Y, et al., Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. FEBS Lett. 2002 Jun 19;521(1-3):67-71
All:	5 reference(s)