Pdgfbtm3Cbet
Targeted Allele Detail
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Symbol: |
Pdgfbtm3Cbet |
Name: |
platelet derived growth factor, B polypeptide; targeted mutation 3, Christer Betsholtz |
MGI ID: |
MGI:2670572 |
Gene: |
Pdgfb Location: Chr15:79880075-79899178 bp, - strand Genetic Position: Chr15, 37.85 cM, cytoband E
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Alliance: |
Pdgfbtm3Cbet page
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A stop codon was inserted into exon 6 via homologous recombination of a targeting vector which also included a loxP flanked neo cassette in intron 5. The insertion of the stop codon precludes the translation of the retention moftif. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Pdgfbtm3.1Cbet.
(J:84701)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pdgfb Mutation: |
15 strains or lines available
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Original: |
J:84701 Lindblom P, et al., Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev. 2003 Aug 1;17(15):1835-40 |
All: |
3 reference(s) |
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