Mybpc3tm1Jse
Targeted Allele Detail
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Symbol: |
Mybpc3tm1Jse |
Name: |
myosin binding protein C, cardiac; targeted mutation 1, Jonathan G Seidman |
MGI ID: |
MGI:2654419 |
Synonyms: |
MyBP-CMUT, MyBP-C(Neo), MyBP-Ct |
Gene: |
Mybpc3 Location: Chr2:90948489-90966861 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E1
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Alliance: |
Mybpc3tm1Jse page
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Germline Transmission: |
Earliest citation of germline transmission:
J:58295
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The gene was disrupted by insertion of a floxed PGK-neo cassette into exon 30 via homologous recombination. The mutant allele generates a transcript that skips exon 30 and that codes for a peptide that contains 32 novel residues and is 174 amino acids shorter than the wild-type peptide.
(J:58295)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mybpc3 Mutation: |
42 strains or lines available
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Original: |
J:58295 McConnell BK, et al., Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice [published erratum appears in J Clin Invest 1999 Dec;104(12):1771]. J Clin Invest. 1999 Nov;104(9):1235-44 |
All: |
28 reference(s) |
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