Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abcc1tm1Acs
Name:	ATP-binding cassette, sub-family C member 1; targeted mutation 1, Alan C Sartorelli
MGI ID:	MGI:2653091
Synonyms:	mrp(-)
Gene:	Abcc1  Location: Chr16:14179317-14292743 bp, + strand  Genetic Position: Chr16, 9.75 cM
Alliance:	Abcc1tm1Acs page

Germline Transmission:	Earliest citation of germline transmission: J:44305
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.7 kb genomic fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included sequence encoding a portion of the B motif of the putative ATP-binding domain. Protein was undetected by Western blot analysis of homozygous mutant mice. (J:44305)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcc1 Mutation:	75 strains or lines available

Original:	J:44305 Lorico A, et al., Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res. 1997 Dec 1;57(23):5238-42
All:	12 reference(s)