Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ltftm1Omc
Name:	lactotransferrin; targeted mutation 1, Orla M Conneely
MGI ID:	MGI:2448243
Synonyms:	LFKO-
Gene:	Ltf  Location: Chr9:110848360-110871834 bp, + strand  Genetic Position: Chr9, 60.79 cM, cytoband F
Alliance:	Ltftm1Omc page

Germline Transmission:	Earliest citation of germline transmission: J:81005
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The iron binding domain was disrupted with a neomcycin selection cassette that replaced a portion of exon 5 through exon 9. Protein was undetected by Western blot analysis of milk obtained from homozygous mutant mice. (J:81005)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ltf Mutation:	40 strains or lines available

Original:	J:81005 Ward PP, et al., Iron status in mice carrying a targeted disruption of lactoferrin. Mol Cell Biol. 2003 Jan;23(1):178-85
All:	2 reference(s)