Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mnx1tm1Jhk
Name:	motor neuron and pancreas homeobox 1; targeted mutation 1, John H Kehrl
MGI ID:	MGI:2447781
Synonyms:	Hlxb9-
Gene:	Mnx1  Location: Chr5:29678821-29683468 bp, - strand  Genetic Position: Chr5, 15.04 cM
Alliance:	Mnx1tm1Jhk page

Germline Transmission:	Earliest citation of germline transmission: J:57314
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 3 was flanked with a neo cassette and loxP sites via homologous recombination. Transient expression of cre recombinase in correctly targeted ES cells facilitated removal of the neo cassette and exon 3 leaving behind a single loxP site in its place. Exon 3 encodes the C-terminal portion of the homeodomain and the remainder of the protein. (J:57314)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mnx1 Mutation:	28 strains or lines available

Original:	J:57314 Harrison KA, et al., Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet. 1999 Sep;23(1):71-5
All:	11 reference(s)