Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Muc1tm1Gend
Name:	mucin 1, transmembrane; targeted mutation 1, Sandra J Gendler
MGI ID:	MGI:2447730
Synonyms:	Muc-1-, Muc1-
Gene:	Muc1  Location: Chr3:89136364-89140688 bp, + strand  Genetic Position: Chr3, 39.02 cM
Alliance:	Muc1tm1Gend page

Germline Transmission:	Earliest citation of germline transmission: J:30128
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A lacZ-neo construct was inserted in frame into exon 1, placing the reporter under the control of the endogenous promoter. Transcript was undetected by Northern blot analysis of homozygous mutant mice. A lack of normal protein was indicated by immunohistochemical analysis of secretory epithelial tissue obtained from homozygous mutant mice. The authors reported that the expression of lacZ did not recapitulate endogenous expression. (J:30128)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Muc1 Mutation:	37 strains or lines available

Original:	J:30128 Spicer AP, et al., Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem. 1995 Dec 15;270(50):30093-101
All:	39 reference(s)