Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ntstm1Dob
Name:	neurotensin; targeted mutation 1, Paul R Dobner
MGI ID:	MGI:2446607
Synonyms:	NT-
Gene:	Nts  Location: Chr10:102317617-102326294 bp, - strand  Genetic Position: Chr10, 53.56 cM, cytoband D1
Alliance:	Ntstm1Dob page

Germline Transmission:	Earliest citation of germline transmission: J:80590
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding the precursor protein signal sequence was replaced with a cassette containing beta-galactosidase and neomyicin resistance genes. Transcript was undetected by Northern blot analysis of intestinal and brain samples obtained from homozygous mutant mice. Similarly, radioimmunoassay of HPLC-fractioned brain extracts and immunohistochemical analysis of brain sections indicated an absence of normal protein. Expression of the beta-galactosidase gene was not detected by staining. (J:80590)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nts Mutation:	18 strains or lines available

Original:	J:80590 Dobner PR, et al., Neurotensin-deficient mice show altered responses to antipsychotic drugs. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8048-53
All:	8 reference(s)