Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Igs16tm1.1Ddu
Name:	intergenic site 16; targeted mutation 1.1, Denis Duboule
MGI ID:	MGI:2445962
Synonyms:	Evx2/Hoxd13tm3.1Ddu, HoxDRXII, L1
Gene:	Igs16  Location: unknown  Genetic Position: Chr2, Syntenic
Alliance:	Igs16tm1.1Ddu page

Germline Transmission:	Earliest citation of germline transmission: J:80084
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Intergenic deletion   Mutation details: A single loxP site was left in place of region 12 between Evx2 and Hoxd13 after the floxed neo cassette was excised from Evx2/Hoxd13tm3Ddu via in vivo cre mediated recombination. Expression analysis of Hoxd genes indicated that deletion of region 12 was insufficient to affect Hoxd expression unless coupled with a deletion of regions 11 and 10. (J:80084)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igs16 Mutation:	1 strain or line available

Original:	J:80084 Kmita M, et al., Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells. Development. 2002 Dec;129(23):5521-8
All:	2 reference(s)